drugset / Trial / NCT03356457

Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes

NCT03356457

Phase 0 Completed 21 enrolled Yale University
RandomizedCrossoverSingle-blindTreatment

Summary

To determine the effect of re-activation of brain glucose metabolism induced by dichloroacetate (DCA) on cognitive function and counterregulatory hormone responses in patients with type 1 diabetes (T1DM) with recurrent hypoglycemia.

Timeline

Start
2017-11-30
Primary completion
2019-03-20
Completion
2019-03-20

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dichloroacetate Small molecule 12.5 mg/kg

Indications