Immunogenicity of Co-administered Yellow Fever and Measles, Mumps, and Rubella (MMR) Vaccines

Phase 4 Completed 851 enrolled Alba Maria Ropero Centers for Disease Control and Prevention · collab Ministry of Public Health, Argentina · collab

RandomizedParallel-groupOpen-labelPrevention

Summary

This study evaluates seroconversion against measles, mumps, rubella and yellow fever following vaccination. One-third of children will receive both yellow fever and measles, mumps, and rubella (MMR) vaccines on the same day; one- third of children will receive MMR vaccine at enrollment followed by yellow fever vaccine 4 weeks later; one-third of children will receive yellow fever vaccine at enrollment followed by MMR vaccine 4 weeks later.

Timeline

Start: 2015-11-23
Primary completion: 2018-06
Completion: 2018-06-30

Publications

Vizzotti C, Harris JB, Aquino A, Rancano C, Biscayart C, Bonaventura R, Pontoriero A, Baumeister E, Freire MC, Magarinos M, Duarte B, Grant G, Reef S, Laven J, Wannemuehler KA, Alvarez AMR, Staples JE. Immune response to co-administration of measles, mumps, and rubella (MMR), and yellow fever vaccines: a randomized non-inferiority trial among one-year-old children in Argentina. BMC Infect Dis. 2023 Mar 17;23(1):165. doi: 10.1186/s12879-023-08114-1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	MMR vaccine	Vaccine	—	—
Subject	Yellow Fever Vaccine	Vaccine	—	—

Indications

No indication recorded.