drugset / Trial / NCT03377556
Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer
NaSingle-groupOpen-labelTreatment
Summary
This phase II trial studies how well talazoparib works in treating patients with homologous recombination repair deficiency (HRRD) positive stage IV squamous cell lung cancer that has come back after previous treatment. Talazoparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Timeline
- Start
- 2017-03-03
- Primary completion
- 2021-01-10
- Completion
- 2021-04-16
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Talazoparib | Small molecule | — | Oral |
Indications
ATM-related cancer predisposition
BARD1-related cancer predisposition
BRCA1-related cancer predisposition
BRCA2-related cancer predisposition
CHEK2-related cancer predisposition
FANCM Fanconi-like genomic instability disorder
Fanconi anemia complementation group A
Fanconi anemia complementation group C
Fanconi anemia complementation group D2
Fanconi anemia complementation group F
Fanconi anemia complementation group J
Fanconi anemia complementation group R
Nijmegen breakage syndrome
PALB2-related cancer predisposition
Seckel syndrome 1
non-small cell squamous lung carcinoma