Study to Compare the Bioavailability of Omeprazole 20 mg Before and After Undergoing Surgery for Morbid Obesity

Summary

The principal aim was to evaluate whether gastric bypass surgery modifies the bioavailability of omeprazole 20 mg at one month and six months after surgery. Other objectives were: * To compare bioavailability of omeprazole 20 mg between patients undergo gastric bypass surgery and patients who avoid it. * To asses other pharmacokinetic parameters, demographic parameters and drug safety. Study design It was planned a mixed design which intended to compare the bioavailability in patients with gastric bypass (before and after surgery) and control subjects matched by sex and body mass index (BMI) post-surgery. This was a single-dose, open-label, crossover bioavailability study of omeprazole in surgical group and controls.

Timeline

Start

2014-10-31

Primary completion

2015-12-23

Completion

2016-02-29

Drugs

Indications

No indication recorded.