drugset / Trial / NCT03379181
Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy
NaSingle-groupOpen-labelBasic science
Summary
The overall objective of the HEAT study is to determine the acute effect of propranolol on energy expenditure in patients suffering from hyperthyroidism and to evaluate the consequences of the change of hyper- to euthyroidism on metabolism during the course of treatment, especially with regard to the reaction to cold ambient temperatures.
Timeline
- Start
- 2017-07-18
- Primary completion
- 2020-02-12
- Completion
- 2020-02-12
Publications
- Senn JR, Loliger RC, Fischer JGW, Bur F, Maushart CI, Betz MJ. Acute effect of propranolol on resting energy expenditure in hyperthyroid patients. Front Endocrinol (Lausanne). 2023 Jan 19;13:1026998. doi: 10.3389/fendo.2022.1026998. eCollection 2022.
- Maushart CI, Senn JR, Loeliger RC, Siegenthaler J, Bur F, Fischer JGW, Betz MJ. Resting Energy Expenditure and Cold-induced Thermogenesis in Patients With Overt Hyperthyroidism. J Clin Endocrinol Metab. 2022 Jan 18;107(2):450-461. doi: 10.1210/clinem/dgab706.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Propranolol | Small molecule | 80 mg | Oral |