Platelet Rich Plasma for Patients With Recurrent Implantation Failure

Summary

Patients with recurrent implantation failure are among the most difficult patients to treat, with no proven standard treatment. Platelet rich plasma stimulates cellular processes involved in endometrial regeneration, and in a small case series has shown efficacy for this patient population. We hope to conduct a randomized controlled pilot study to determine whether PRP is indeed an effective treatment for recurrent implantation failure.

Timeline

Start

2019-01-16

Primary completion

2023-12-20

Completion

2023-12-20

Outcome

Missed primary endpoint

paper PR was 69% in the PRP group vs 50% in controls (p = 0.27) PMID 41247443 ↗

Publications

• Background Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Ajori L. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. Int J Reprod Biomed. 2016 Oct;14(10):625-628.
• Aghajanova L, Strug M, Zhang J, Lathi RB. Intrauterine platelet-rich plasma infusion for recurrent implantation failure: a pilot randomized controlled single-blinded clinical trial in the USA. J Assist Reprod Genet. 2026 Feb;43(2):639-650. doi: 10.1007/s10815-025-03752-7. Epub 2025 Nov 17.

Drugs

Indications