Effect of Cimetidine on the Pharmacokinetics of Lucerastat in Healthy Subjects

Phase 1 Completed 14 enrolled Idorsia Pharmaceuticals Ltd.

NaSequentialOpen-labelOther

Summary

A study in healthy male subjects to investigate whether repeated administrations of cimetidine (a medication which decreases the amount of acid in the stomach) can affect the fate in the body (amount and time of presence in the blood) of lucerastat. Safety of the concomitant administration of the two treatments will also be assessed.

Timeline

Start: 2018-01-09
Primary completion: 2018-01-29
Completion: 2018-01-29

Publications

Boof ML, Halabi A, Ufer M, Dingemanse J. Impact of the organic cation transporter 2 inhibitor cimetidine on the single-dose pharmacokinetics of the glucosylceramide synthase inhibitor lucerastat in healthy subjects. Eur J Clin Pharmacol. 2020 Mar;76(3):431-437. doi: 10.1007/s00228-019-02808-9. Epub 2019 Dec 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cimetidine	Small molecule	800 mg	Oral
Subject	Lucerastat	Small molecule	500 mg	Oral

Indications

No indication recorded.