Regulation of Endogenous Glucose Production by Brain Insulin Action in Insulin Resistance

Summary

It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production. Animal studies have shown that the hormone insulin can act on the brain to indirectly lower glucose production by the liver. It has previously been shown that a nasal spray can deliver insulin directly to the brain without affecting circulating insulin concentration in humans. Intranasal spray of insulin suppressed hepatic glucose production in lean subjects. It is unknown whether this effects is blunted in subjects with insulin resistance.

Timeline

Start

2015-09-08

Primary completion

2017-07-31

Completion

2017-12-01

Drugs

Indications