drugset / Trial / NCT03389750
A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists.
RandomizedCrossoverDouble-blindBasic science
Summary
Significant public health concerns have arisen from the intravenous misuse of oxymorphone, a potent mu-opioid pain medication. However, little is known about its abuse potential relative to other mu-opioid analgesics. The present study is designed to examine the abuse liability of intravenous oxymorphone compared to other mu opioid agonists (oxycodone, and hydromorphone) among physically dependent opioid abusers.
Timeline
- Start
- 2018-03-15
- Primary completion
- 2022-06-15
- Completion
- 2023-06-28
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Hydromorphone | Other / unclassified | 3.2 mg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 5.6 mg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 10 mg | Intravenous |
| Comparator | Hydromorphone | Other / unclassified | 18 mg | Intravenous |
| Comparator | Oxycodone | Other / unclassified | 10 mg | Intravenous |
| Comparator | Oxycodone | Other / unclassified | 18 mg | Intravenous |
| Comparator | Oxycodone | Other / unclassified | 32 mg | Intravenous |
| Comparator | Oxycodone | Other / unclassified | 56 mg | Intravenous |
| Comparator | Oxymorphone | Small molecule | 1.8 mg | Intravenous |
| Comparator | Oxymorphone | Small molecule | 3.2 mg | Intravenous |
| Comparator | Oxymorphone | Small molecule | 5.6 mg | Intravenous |
| Comparator | Oxymorphone | Small molecule | 10 mg | Intravenous |