Metabolic Effects of Natriuretic Peptide Hormones

Summary

Accumulating evidence suggests that the natriuretic peptide (NP) hormonal system has important effects on metabolism. However, more information is needed to better understand the effects of NPs on metabolism in humans. Therefore, the investigators propose a study to determine the effects of b-type natriuretic peptide (BNP) on energy and fat metabolism in humans. The investigators' primary hypothesis is that the administration of BNP will increase energy expenditure in humans. The investigators' secondary hypothesis is that BNP administration will promote changes in gene expression in fat tissue suggestive of fat "beiging" in humans. Interventions that safely increase energy expenditure and promote fat "beiging" represent potential strategies for treating metabolic dysfunction due to obesity.

Timeline

Start

2018-07-01

Primary completion

2019-05-01

Completion

2019-05-01

Outcome

Missed primary endpoint

Stopped: “Study drug no longer available”

registry analysis (superiority test); BNP Infusion vs Placebo (Control); p = 0.063; Mixed Models Analysis NCT03397966 ↗

Publications

• Bachmann KN, Ceddia RP, Gupta DK, Collins S, Wang TJ. Human adipose tissue expression of uncoupling protein 1 in response to intravenous administration of B-type natriuretic peptide hormone: Results from a randomized controlled crossover study. Diabetes Obes Metab. 2024 Aug;26(8):3458-3461. doi: 10.1111/dom.15628. Epub 2024 Apr 30. No abstract available.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	BNP(1-32)	Peptide	10 unknown	Intravenous

Indications