drugset / Trial / NCT03401515
Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon
RandomizedParallel-groupDouble-blindTreatment
Summary
Traumatic Brain Injury (TBI) is one of the leading causes of death. Severe TBT is correlated with an exaggerated stress response due to plasma catecholamine levels known as sympathetic storming. It is also autonomic dysfunction syndrome. This phenomenon is also associated with brain tumors, severe hydrocephalus and subarachnoid hemorrhage. Patients are presented by tachycardia, tachypnea hypertension, diaphoresis, dystonia, hyperthermia, and dilated pupils with elevated levels of plasma catecholamine and blood glucose .
Timeline
- Start
- 2016-10-01
- Primary completion
- 2017-06-10
- Completion
- 2017-08-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Propranolol | Small molecule | 1 mg | — |