drugset / Trial / NCT03401515

Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon

NCT03401515

Phase 4 Completed 60 enrolled Ain Shams University
RandomizedParallel-groupDouble-blindTreatment

Summary

Traumatic Brain Injury (TBI) is one of the leading causes of death. Severe TBT is correlated with an exaggerated stress response due to plasma catecholamine levels known as sympathetic storming. It is also autonomic dysfunction syndrome. This phenomenon is also associated with brain tumors, severe hydrocephalus and subarachnoid hemorrhage. Patients are presented by tachycardia, tachypnea hypertension, diaphoresis, dystonia, hyperthermia, and dilated pupils with elevated levels of plasma catecholamine and blood glucose .

Timeline

Start
2016-10-01
Primary completion
2017-06-10
Completion
2017-08-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Propranolol Small molecule 1 mg