Impact of Carbetocin Administration on Heart Rate When Given as an Infusion Versus as a Bolus.

Summary

Prospective, randomized and controlled study who will be conducted at Maisonneuve-Rosemont hospital with the following objectives: To determine if an infusion of carbetocin over 10 minutes will reduce hemodynamic side effects, especially the peak of heart rate, in comparison to a rapid intravenous bolus (less than 2 seconds). To determine if an infusion of carbetocin will reduce the other side effects of duratocin in comparison to a rapid intravenous bolus. Study plans to enroll 70 adult patients scheduled to undergo elective cesarean delivery under spinal anesthesia. Half of the patient will receive Carbetocin 100 mcg intravenous as a bolus (less than 2 seconds) and the other half will receive Carbetocin 100 mcg intravenous infusion over 10 minutes.

Timeline

Start

2018-06-11

Primary completion

2020-01-28

Completion

2021-01-15

Publications

• Boisselle ME, Zaphiratos VV, Fortier A, Richebe P, Loubert C. Comparison of carbetocin as a bolus or an infusion with prophylactic phenylephrine on maternal heart rate during Cesarean delivery under spinal anesthesia: a double-blinded randomized controlled trial. Can J Anaesth. 2022 Jun;69(6):715-725. doi: 10.1007/s12630-022-02227-y. Epub 2022 Mar 30.

Drugs

Indications

No indication recorded.