Red Blood Cell ATP Release and Vascular Function in Humans

Summary

Previous work demonstrates that the red blood cells of older adults do not release a potent vasodilator (ATP) as well as the red blood cells of younger adults. The investigators are targeting a pathway within the red blood cell using fasudil hydrochloride to determine if both the release of ATP from red blood cells and blood flow responses to low oxygen (hypoxia) and exercise in older adults can be improved.

Timeline

Start

2017-07-14

Primary completion

2018-10-05

Completion

2018-10-05

Drugs

Indications