Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain

Summary

Breast cancer is the most frequent neoplastic tumor in women, and surgical treatment is indicated in most patients. Complications related to this treatment, such as post-mastectomy pain syndrome (PMPS), a persistent pain that develops after surgery, have been reported. Although the genesis of the pain is multifactorial, sectioning of the intercostobrachial nerve is the nerve lesion diagnosed more often (1) .. Pain relief using drugs with high efficacy provides significant improvement in the patients' lives. Drugs like lamotrigine (LTG) and gabapentin (GBP) have the ability to overcome the symptoms of neuropathic pain (4). Both LTG and PGB have been extensively reviewed in the past for management of painful neuropathic conditions (5)

Timeline

Start

—

Primary completion

—

Completion

—

Publications

• Background Couceiro TC, Menezes TC, Valenca MM. Post-mastectomy pain syndrome: the magnitude of the problem. Rev Bras Anestesiol. 2009 May-Jun;59(3):358-65. doi: 10.1590/s0034-70942009000300012. English, Portuguese.
• Background Maigaard S, Forman A, Andersson KE. Differences in contractile activation between human myometrium and intramyometrial arteries. Acta Physiol Scand. 1985 Jul;124(3):371-9. doi: 10.1111/j.1748-1716.1985.tb07672.x.
• Background Panic A, Mijatovic D, Radosavac B. [The role of secondary prevention of alcoholism in the development of alcoholic epilepsy]. Med Pregl. 1986;39(9-10):445-8. No abstract available. Croatian.
• Background Szabo AZ, Bocsan IC, Suciu S, Buzoianu AD. Comparative animal study of the antinociceptive efficacy of lamotrigine and gabapentin for the management of pain. Acta Physiol Hung. 2015 Dec;102(4):363-71. doi: 10.1556/036.102.2015.4.3.
• Background Hunter JC, Gogas KR, Hedley LR, Jacobson LO, Kassotakis L, Thompson J, Fontana DJ. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. Eur J Pharmacol. 1997 Apr 18;324(2-3):153-60. doi: 10.1016/s0014-2999(97)00070-8.
• Background Taylor JC, Brauer S, Espir ML. Long-term treatment of trigeminal neuralgia with carbamazepine. Postgrad Med J. 1981 Jan;57(663):16-8. doi: 10.1136/pgmj.57.663.16.
• Background Bertilsson L. Clinical pharmacokinetics of carbamazepine. Clin Pharmacokinet. 1978 Mar-Apr;3(2):128-43. doi: 10.2165/00003088-197803020-00003.
• Background Spina E, Pisani F, Perucca E. Clinically significant pharmacokinetic drug interactions with carbamazepine. An update. Clin Pharmacokinet. 1996 Sep;31(3):198-214. doi: 10.2165/00003088-199631030-00004.
• Background Guay DR. Pregabalin in neuropathic pain: a more "pharmaceutically elegant" gabapentin? Am J Geriatr Pharmacother. 2005 Dec;3(4):274-87.
• Background Frampton JE, Foster RH. Pregabalin: in the treatment of postherpetic neuralgia. Drugs. 2005;65(1):111-8; discussion 119-20. doi: 10.2165/00003495-200565010-00011.
• Background Agarwal A, Gautam S, Gupta D, Agarwal S, Singh PK, Singh U. Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy. Br J Anaesth. 2008 Nov;101(5):700-4. doi: 10.1093/bja/aen244. Epub 2008 Aug 20.
• Background Burke SM, Shorten GD. Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy. Anesth Analg. 2010 Apr 1;110(4):1180-5. doi: 10.1213/ANE.0b013e3181cf949a. Epub 2010 Jan 26.
• Background Buvanendran A, Kroin JS, Della Valle CJ, Kari M, Moric M, Tuman KJ. Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial. Anesth Analg. 2010 Jan 1;110(1):199-207. doi: 10.1213/ANE.0b013e3181c4273a. Epub 2009 Nov 12.
• Background Rustagi A, Roychoudhury A, Bhutia O, Trikha A, Srivastava MV. Lamotrigine Versus Pregabalin in the Management of Refractory Trigeminal Neuralgia: A Randomized Open Label Crossover Trial. J Maxillofac Oral Surg. 2014 Dec;13(4):409-18. doi: 10.1007/s12663-013-0513-8. Epub 2013 May 24.

Drugs

Indications

No indication recorded.