drugset / Trial / NCT03420469
Bupropion Stereoselective Disposition and CYP2D6-mediated Drug Interactions in Healthy Volunteers
Phase 0
Completed
28 enrolled
Indiana University
National Institute of General Medical Sciences (NIGMS) · collab
Non-randomizedSequentialOpen-labelBasic science
Summary
Primary objectives: 1. To comprehensively characterize steady state stereoselective pharmacokinetics of bupropion and its primary and secondary metabolites in healthy volunteers 2. To prospectively determine the time course (onset), extent and offset of CYP2D6 inhibition in relation to the pharmacokinetic profiles of bupropion and metabolites.
Timeline
- Start
- 2018-06-05
- Primary completion
- 2019-05-01
- Completion
- 2019-05-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupropion | Small molecule | 150 mg | Oral |