Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy

Phase 0 Active not recruiting 82 enrolled City of Hope Medical Center National Cancer Institute (NCI) · collab

Non-randomizedParallel-groupOpen-labelDiagnostic

Summary

This clinical trial investigates multi-modality imaging and collection of biospecimen samples in understanding bone marrow changes in patients with acute myeloid leukemia undergoing total body irradiation (TBI) and chemotherapy. Using multi-modality imaging and collecting biospecimen samples may help doctors know more about how TBI and chemotherapy can change the bone marrow.

Timeline

Start: 2018-02-15
Primary completion: 2026-11-06
Completion: 2026-11-06

Publications

Malekzadeh M, Ghimire H, Popuri K, Fujita K, Salhotra A, Yamauchi D, Chen B, Froelich J, Storme G, Stein A, Beg MF, Wong J, Malki MMA, Hui SK. AI-Driven Bone and Marrow Segmentation on FLT-PET/CT: Technical Multi-organ Validation in AML and HCT. Res Sq [Preprint]. 2026 Apr 19:rs.3.rs-9077609. doi: 10.21203/rs.3.rs-9077609/v1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	18F-FLT	Diagnostic / imaging agent	—	—

Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy

Summary

Timeline

Publications

Drugs

Indications