OxSYPan: Oxford Study With Young People on Antidepressants

Summary

Fluoxetine is commonly used to treat adolescent depression, but the neural mechanisms underlying antidepressant drugs in the young brain are still poorly understood. This study proposes to investigate the effects of a single dose of fluoxetine on emotional neural processing in a sample of depressed adolescents, using functional Magnetic Resonance Imaging (fMRI).

Timeline

Start

2012-05-23

Primary completion

2015-11-10

Completion

2015-11-10

Publications

• Background Capitao LP, Murphy SE, Browning M, Cowen PJ, Harmer CJ. Acute fluoxetine modulates emotional processing in young adult volunteers. Psychol Med. 2015 Aug;45(11):2295-308. doi: 10.1017/S0033291715000240. Epub 2015 Apr 13.
• Background American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th edn: DSM-5. American Psychiatric Association: Arlington, VA.
• Capitao LP, Chapman R, Filippini N, Wright L, Murphy SE, James A, Cowen PJ, Harmer CJ. Acute neural effects of fluoxetine on emotional regulation in depressed adolescents. Psychol Med. 2023 Jul;53(10):4799-4810. doi: 10.1017/S0033291722001805. Epub 2022 Jul 29.

Drugs

Indications