Effects of Vitamin B12 Treatment in Singers

Phase 0 Completed 20 enrolled University of Southern California

RandomizedCrossoverTriple-blindTreatment

Summary

In this study, the investigators aim to assess if vitamin B12 treatment demonstrates a beneficial effect on voice performance. If so, they wish to examine the relationship between the vitamin B12 treatment and the study participant's general well-being.

Timeline

Start: 2017-10-01
Primary completion: 2019-04-01
Completion: 2019-04-01

Outcome

Missed primary endpoint

paper The median difference between differences at 72 hours between placebo and vitamin B12 injections were 1.5 (95% CI, -2 to 5) for the SVHI-10 PMID 33180098 ↗

paper the improvement in self-reported voice measures in singers shows no meaningful difference compared with placebo. PMID 33180098 ↗

Publications

Shoffel-Havakuk H, Lava CX, Reuven Y, Moog D, Odell K, Reder LS, Hapner ER, Johns MM 3rd. Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Controlled, Crossover Trial. JAMA Otolaryngol Head Neck Surg. 2021 Jan 1;147(1):9-15. doi: 10.1001/jamaoto.2020.4026.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Vitamin B12	Other / unclassified	1000 mg	Intramuscular