Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure

Phase 0 Completed 50 enrolled Yale University National Heart, Lung, and Blood Institute (NHLBI) · collab

RandomizedParallel-groupTriple-blindDiagnostic

Summary

The purpose of this study is to understand the effects of chloride supplementation on volume-overloaded acute heart failure patients concomitantly treated with IV diuretics.

Timeline

Start: 2018-07-12
Primary completion: 2022-09-07
Completion: 2022-09-07

Publications

Kazory A. Combination Diuretic Therapy to Counter Renal Sodium Avidity in Acute Heart Failure: Trials and Tribulations. Clin J Am Soc Nephrol. 2023 Oct 1;18(10):1372-1381. doi: 10.2215/CJN.0000000000000188. Epub 2023 Apr 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lysine	Other / unclassified	115 mmol	—

Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure

Summary

Timeline

Publications

Drugs

Indications