Analgesia Effects of Intravenous Ketamine After Spinal Anesthesia for Non-elective Cesarean Section

Phase 4 Completed 80 enrolled B.P. Koirala Institute of Health Sciences

RandomizedParallel-groupDouble-blindTreatment

Summary

This randomized double blind study will be conducted in pregnant woman planned for non elective cesarean section under spinal anesthesia. Ketamine group will receive intravenous 0.25 mg/kg and placebo group will receive same amount of normal saline after spinal anesthesia prior to skin incision. Postoperative outcomes measures are total opioid consumption and pain scores for 24 hrs.

Timeline

Start: 2018-04-01
Primary completion: 2019-03-07
Completion: 2019-03-07

Outcome

Met primary endpoint

paper 0 (0-4.67) mg in ketamine group and 1 (0-6) mg in saline group (p=0.003). PMID 34193480 ↗

Publications

Adhikari P, Subedi A, Sah BP, Pokharel K. Analgesic effects of intravenous ketamine after spinal anaesthesia for non-elective caesarean delivery: a randomised controlled trial. BMJ Open. 2021 Jun 30;11(6):e044168. doi: 10.1136/bmjopen-2020-044168.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	0.25 mg/kg	Intravenous

Indications

No indication recorded.