The Effect of an Antibiotic on the Production of Uremic Toxins by the Gut Microbiome

Summary

The purpose of this study is to determine if multiple doses of vancomycin over the course of 3 months will perturb the intestinal flora (microbiome) and result in reduced serum concentration of the uremic toxin indoxyl sulfate and p-cresyl sulfate. The design of the study will permit investigators to assess the variability of serum uremic retention solute concentrations with and without antibiotic over a three-month period.

Timeline

Start

2017-11-27

Primary completion

2018-08-18

Completion

2018-08-18

Drugs

Indications