Efficacy of Doxycycline in the Treatment of Early Stages of Mycosis Fungoides

Summary

Current study aims at assessing the efficacy of doxycycline as a potential treatment modality for early stages of MF.

Timeline

Start

2017-03-01

Primary completion

2019-04-01

Completion

2019-04-01

Outcome

Missed primary endpoint

paper Doxycycline achieved significantly less ORR (partial response) in comparison to PUVA (11.1%, 50%, respectively, p = .016). PMID 31526286 ↗

Publications

• Valipour A, Jager M, Wu P, Schmitt J, Bunch C, Weberschock T. Interventions for mycosis fungoides. Cochrane Database Syst Rev. 2020 Jul 7;7(7):CD008946. doi: 10.1002/14651858.CD008946.pub3.
• El Sayed H, Shalaby S, Abdel-Halim MRE, Aboelfadl DM, Samir N. Efficacy of doxycycline in the treatment of early stages of mycosis fungoides: a randomized controlled trial. J Dermatolog Treat. 2021 Jun;32(4):424-431. doi: 10.1080/09546634.2019.1667474. Epub 2019 Sep 20.

Drugs

Indications