Pregabalin Stabilize Cardiovascular Response to Intubation

Phase 4 Completed 90 enrolled Shanghai Zhongshan Hospital

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of the study is to evaluate whether Pregabalin is safe and effective in stabilizing cardiovascular response to laryngoscopy and tracheal intubation of patients under general anesthesia.

Timeline

Start: 2017-01-01
Primary completion: 2017-06-30
Completion: 2017-06-30

Publications

Chen W, Huang H, Yang C, Hu X, Bao F, Jiang H. Preoperative Low-dose and High-dose Pregabalin and Cardiovascular Response to Endotracheal Intubation: A Prospective, Randomized, Single-blind, Controlled Study in China. Clin Ther. 2019 Jan;41(1):68-77. doi: 10.1016/j.clinthera.2018.11.006. Epub 2018 Dec 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pregabalin	Small molecule	150 mg	Oral
Subject	Pregabalin	Small molecule	300 mg	Oral

Indications

No indication recorded.