drugset / Trial / NCT03468777
A Crossover Study to Assess the Drug-drug Interaction of Acid Reducing Agent(s) on the Pharmacokinetics of a Single Oral Dose of Lumicitabine (JNJ-64041575) in Healthy Adult Participants
RandomizedCrossoverOpen-labelOther
Summary
The main purpose of study is to evaluate the effect of multiple-dose administration of lansoprazole (and optional: time-separated single dose administration of ranitidine) on the pharmacokinetics (PK) of JNJ-63549109 after a single dose of lumicitabine in healthy adult participants, under fasted (and optional: fed) conditions.
Timeline
- Start
- 2018-03-06
- Primary completion
- 2018-07-09
- Completion
- 2018-07-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lansoprazole | Other / unclassified | 30 mg | Oral |
| Subject | Lumicitabine | Small molecule | 1000 mg | Oral |
| Subject | Ranitidine | Unknown | 150 mg | Oral |
Indications
No indication recorded.