Assessment of Coagulation Factor Levels in Left Ventricular Device (LVAD )Patients Following Temporary Warfarin Reversal With Four Factor Prothrombin Complex Concentrate (4F-PCC)

Phase 4 Unknown 50 enrolled Brigham and Women's Hospital CSL Behring · collab

NaSingle-groupOpen-labelTreatment

Summary

Prospective assessment of vitamin K dependent coagulation factor levels after temporary warfarin reversal in participants with left ventricular assist devices (LAVD).

Timeline

Start: 2018-03-15
Primary completion: 2021-12-31
Completion: 2022-03-31

Publications

Sylvester KW, Grandoni J, Rhoten M, Coakley L, Lyons-Matiello E, Frankel K, Fortin B, Jolley K, Park HS, Freedman RY, Mehra MR, Givertz MM, Connors JM. Assessment of Temporary Warfarin Reversal in Patients With Left Ventricular Assist Devices: the KVAD Study. J Card Fail. 2024 Sep;30(9):1111-1119. doi: 10.1016/j.cardfail.2024.02.022. Epub 2024 Mar 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Prothrombin Complex Concentrate	Protein / enzyme biologic	—	—

Indications

No indication recorded.