Effectiveness of Contrast-Enhanced Ultrasound

Summary

The purpose of the study is to generate pilot data describing test characteristics of contrast enhanced ultrasound in young children with concern for abdominal trauma. The primary objective in this study is to determine the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) compared to abdominal Computed Tomography (CT) in the detection of abdominal solid organ injury in young children \< 8 years of age with concern for blunt abdominal trauma.

Timeline

Start

2018-05-09

Primary completion

2026-12

Completion

2026-12

Publications

• Background Wood J, Rubin DM, Nance ML, Christian CW. Distinguishing inflicted versus accidental abdominal injuries in young children. J Trauma. 2005 Nov;59(5):1203-8. doi: 10.1097/01.ta.0000196437.07011.b1.
• Background Lutz N, Nance ML, Kallan MJ, Arbogast KB, Durbin DR, Winston FK. Incidence and clinical significance of abdominal wall bruising in restrained children involved in motor vehicle crashes. J Pediatr Surg. 2004 Jun;39(6):972-5. doi: 10.1016/j.jpedsurg.2004.02.029.
• Background Carter KW, Moulton SL. Pediatric abdominal injury patterns caused by "falls": A comparison between nonaccidental and accidental trauma. J Pediatr Surg. 2016 Feb;51(2):326-8. doi: 10.1016/j.jpedsurg.2015.10.056. Epub 2015 Oct 31.
• Background Cooper A, Floyd T, Barlow B, Niemirska M, Ludwig S, Seidl T, O'Neill J, Templeton J, Ziegler M, Ross A, et al. Major blunt abdominal trauma due to child abuse. J Trauma. 1988 Oct;28(10):1483-7. doi: 10.1097/00005373-198810000-00015.
• Background Lindberg D, Makoroff K, Harper N, Laskey A, Bechtel K, Deye K, Shapiro R; ULTRA Investigators. Utility of hepatic transaminases to recognize abuse in children. Pediatrics. 2009 Aug;124(2):509-16. doi: 10.1542/peds.2008-2348. Epub 2009 Jul 20.
• Background Lindberg DM, Shapiro RA, Blood EA, Steiner RD, Berger RP; ExSTRA investigators. Utility of hepatic transaminases in children with concern for abuse. Pediatrics. 2013 Feb;131(2):268-75. doi: 10.1542/peds.2012-1952. Epub 2013 Jan 14.
• Background Trout AT, Strouse PJ, Mohr BA, Khalatbari S, Myles JD. Abdominal and pelvic CT in cases of suspected abuse: can clinical and laboratory findings guide its use? Pediatr Radiol. 2011 Jan;41(1):92-8. doi: 10.1007/s00247-010-1847-8. Epub 2010 Oct 9.
• Background Hennes HM, Smith DS, Schneider K, Hegenbarth MA, Duma MA, Jona JZ. Elevated liver transaminase levels in children with blunt abdominal trauma: a predictor of liver injury. Pediatrics. 1990 Jul;86(1):87-90.
• Background Rothrock SG, Green SM, Morgan R. Abdominal trauma in infants and children: prompt identification and early management of serious and life-threatening injuries. Part I: injury patterns and initial assessment. Pediatr Emerg Care. 2000 Apr;16(2):106-15. doi: 10.1097/00006565-200004000-00012.
• Background Goske MJ, Applegate KE, Bulas D, Butler PF, Callahan MJ, Coley BD, Don S, Frush DP, Hernanz-Schulman M, Kaste SC, Morrison G, Sidhu M, Strauss KJ, Treves ST; Alliance for Radiation Safety in Pediatric Imaging. Image Gently: progress and challenges in CT education and advocacy. Pediatr Radiol. 2011 Sep;41 Suppl 2:461-6. doi: 10.1007/s00247-011-2133-0. Epub 2011 Aug 17.
• Background Laugesen NG, Nolsoe CP, Rosenberg J. Clinical Applications of Contrast-Enhanced Ultrasound in the Pediatric Work-Up of Focal Liver Lesions and Blunt Abdominal Trauma: A Systematic Review. Ultrasound Int Open. 2017 Feb;3(1):E2-E7. doi: 10.1055/s-0042-124502.
• Background Miele V, Piccolo CL, Trinci M, Galluzzo M, Ianniello S, Brunese L. Diagnostic imaging of blunt abdominal trauma in pediatric patients. Radiol Med. 2016 May;121(5):409-30. doi: 10.1007/s11547-016-0637-2. Epub 2016 Apr 13.
• Background Catalano O, Aiani L, Barozzi L, Bokor D, De Marchi A, Faletti C, Maggioni F, Montanari N, Orlandi PE, Siani A, Sidhu PS, Thompson PK, Valentino M, Ziosi A, Martegani A. CEUS in abdominal trauma: multi-center study. Abdom Imaging. 2009 Mar-Apr;34(2):225-34. doi: 10.1007/s00261-008-9452-0.
• Background Clevert DA, Weckbach S, Minaifar N, Clevert DA, Stickel M, Reiser M. Contrast-enhanced ultrasound versus MS-CT in blunt abdominal trauma. Clin Hemorheol Microcirc. 2008;39(1-4):155-69.
• Background Manetta R, Pistoia ML, Bultrini C, Stavroulis E, Di Cesare E, Masciocchi C. Ultrasound enhanced with sulphur-hexafluoride-filled microbubbles agent (SonoVue) in the follow-up of mild liver and spleen trauma. Radiol Med. 2009 Aug;114(5):771-9. doi: 10.1007/s11547-009-0406-6. Epub 2009 May 30. English, Italian.
• Background Thorelius L. Emergency real-time contrast-enhanced ultrasonography for detection of solid organ injuries. Eur Radiol. 2007 Dec;17 Suppl 6:F107-11. doi: 10.1007/s10406-007-0235-4.
• Background Valentino M, Serra C, Zironi G, De Luca C, Pavlica P, Barozzi L. Blunt abdominal trauma: emergency contrast-enhanced sonography for detection of solid organ injuries. AJR Am J Roentgenol. 2006 May;186(5):1361-7. doi: 10.2214/AJR.05.0027.
• Background Piscaglia F, Bolondi L; Italian Society for Ultrasound in Medicine and Biology (SIUMB) Study Group on Ultrasound Contrast Agents. The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations. Ultrasound Med Biol. 2006 Sep;32(9):1369-75. doi: 10.1016/j.ultrasmedbio.2006.05.031.
• Background Oldenburg A, Hohmann J, Skrok J, Albrecht T. Imaging of paediatric splenic injury with contrast-enhanced ultrasonography. Pediatr Radiol. 2004 Apr;34(4):351-4. doi: 10.1007/s00247-003-1092-5. Epub 2003 Dec 2.
• Background Valentino M, Serra C, Pavlica P, Labate AM, Lima M, Baroncini S, Barozzi L. Blunt abdominal trauma: diagnostic performance of contrast-enhanced US in children--initial experience. Radiology. 2008 Mar;246(3):903-9. doi: 10.1148/radiol.2463070652. Epub 2008 Jan 14.
• Background Menichini G, Sessa B, Trinci M, Galluzzo M, Miele V. Accuracy of contrast-enhanced ultrasound (CEUS) in the identification and characterization of traumatic solid organ lesions in children: a retrospective comparison with baseline US and CE-MDCT. Radiol Med. 2015 Nov;120(11):989-1001. doi: 10.1007/s11547-015-0535-z. Epub 2015 Mar 31.
• Background Riccabona M. Application of a second-generation US contrast agent in infants and children--a European questionnaire-based survey. Pediatr Radiol. 2012 Dec;42(12):1471-80. doi: 10.1007/s00247-012-2472-5. Epub 2012 Oct 3.
• Background Piskunowicz M, Kosiak W, Batko T, Piankowski A, Polczynska K, Adamkiewicz-Drozynska E. Safety of intravenous application of second-generation ultrasound contrast agent in children: prospective analysis. Ultrasound Med Biol. 2015 Apr;41(4):1095-9. doi: 10.1016/j.ultrasmedbio.2014.11.003. Epub 2015 Feb 18.
• Background Yusuf GT, Sellars ME, Deganello A, Cosgrove DO, Sidhu PS. Retrospective Analysis of the Safety and Cost Implications of Pediatric Contrast-Enhanced Ultrasound at a Single Center. AJR Am J Roentgenol. 2017 Feb;208(2):446-452. doi: 10.2214/AJR.16.16700. Epub 2016 Dec 13.
• Background Jacob J, Deganello A, Sellars ME, Hadzic N, Sidhu PS. Contrast enhanced ultrasound (CEUS) characterization of grey-scale sonographic indeterminate focal liver lesions in pediatric practice. Ultraschall Med. 2013 Dec;34(6):529-40. doi: 10.1055/s-0033-1355785. Epub 2013 Oct 16.
• Background Bonini G, Pezzotta G, Morzenti C, Agazzi R, Nani R. Contrast-enhanced ultrasound with SonoVue in the evaluation of postoperative complications in pediatric liver transplant recipients. J Ultrasound. 2007 Jun;10(2):99-106. doi: 10.1016/j.jus.2007.02.008. Epub 2007 Jun 13.
• Background Knieling F, Strobel D, Rompel O, Zapke M, Menendez-Castro C, Wolfel M, Schulz J, Rascher W, Jungert J. Spectrum, Applicability and Diagnostic Capacity of Contrast-Enhanced Ultrasound in Pediatric Patients and Young Adults after Intravenous Application - A Retrospective Trial. Ultraschall Med. 2016 Dec;37(6):619-626. doi: 10.1055/s-0042-108429. Epub 2016 Jun 14.
• Background Stenzel M. Intravenous contrast-enhanced sonography in children and adolescents - a single center experience. J Ultrason. 2013 Jun;13(53):133-44. doi: 10.15557/JoU.2013.0014. Epub 2013 Jun 30.
• Background Rafailidis V, Deganello A, Watson T, Sidhu PS, Sellars ME. Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications. Br J Radiol. 2017 Jan;90(1069):20160556. doi: 10.1259/bjr.20160556. Epub 2016 Sep 26.

Drugs

Indications

No indication recorded.