drugset / Trial / NCT03474263

IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS)

NCT03474263

Phase 2 Withdrawn Implicit Bioscience
NaSingle-groupOpen-labelTreatment

Summary

Patients with rapidly progressive ALS will be assigned to IC14 intravenously on Day 1-4. This 4-day course will be repeated on Days 8-11. Patients will all undergo MR-PET scans at two time points: before treatment onset and after the last treatment cycle. This scan will measure areas of ALS disease activity and assess response to IC14 treatment. MR-PET scans will be compared to historical controls.

Timeline

Start
2019-09-01
Primary completion
2021-04-12
Completion
2021-07-12

Drugs

EvaluationDrugModalityDoseRoute
Subject IC14 Monoclonal antibody 2 mg/kg Intravenous