drugset / Trial / NCT03474263
IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS)
NaSingle-groupOpen-labelTreatment
Summary
Patients with rapidly progressive ALS will be assigned to IC14 intravenously on Day 1-4. This 4-day course will be repeated on Days 8-11. Patients will all undergo MR-PET scans at two time points: before treatment onset and after the last treatment cycle. This scan will measure areas of ALS disease activity and assess response to IC14 treatment. MR-PET scans will be compared to historical controls.
Timeline
- Start
- 2019-09-01
- Primary completion
- 2021-04-12
- Completion
- 2021-07-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | IC14 | Monoclonal antibody | 2 mg/kg | Intravenous |