Platelet Rich Plasma Versus Minoxidil Foam for Treatment of Androgenic Alopecia in Women

Phase 1/2 Completed 20 enrolled Mayo Clinic

RandomizedCrossoverOpen-labelTreatment

Summary

The primary objective of this proposal is to conduct a study that assesses the safety, feasibility and efficacy of using PRP to treat this type of hair loss.

Timeline

Start: 2017-01-23
Primary completion: 2018-05-31
Completion: 2019-06-17

Outcome

Missed primary endpoint

registry MEDIAN Platelet Rich Plasma: 7.7 (-7.2 to 17.9) percent change NCT03488108 ↗

registry MEDIAN Minoxidil Foam: 22.7 (-18.0 to 59.0) percent change NCT03488108 ↗

registry analysis (superiority test); Platelet Rich Plasma vs Minoxidil Foam; p = .009; Wilcoxon (Mann-Whitney) NCT03488108 ↗

registry analysis (superiority test); Platelet Rich Plasma vs Minoxidil Foam; p = .90; Wilcoxon (Mann-Whitney) NCT03488108 ↗

registry analysis (superiority test); Platelet Rich Plasma vs Minoxidil Foam; p = .003; Wilcoxon (Mann-Whitney) NCT03488108 ↗

registry analysis (superiority test); Platelet Rich Plasma vs Minoxidil Foam; p = .005; Wilcoxon (Mann-Whitney) NCT03488108 ↗

Publications

Bruce AJ, Pincelli TP, Heckman MG, Desmond CM, Arthurs JR, Diehl NN, Douglass EJ, Bruce CJ, Shapiro SA. A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women. Dermatol Surg. 2020 Jun;46(6):826-832. doi: 10.1097/DSS.0000000000002168.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Minoxidil	Small molecule	5 %	Topical