A Study of Human Multi-Sensory Integration

Phase 2 Suspended 40 enrolled University of Pennsylvania

RandomizedParallel-groupOpen-labelBasic science

Summary

The primary aim of this study is to determine whether spatiotemporal characteristics of multisensory evoked potentials can be used as a marker of consciousness (awareness) under anesthesia. The secondary aim is to characterize changes in the characteristics of evoked potentials under anesthesia in both single sensory modality (visual, auditory) and across sensory modalities.

Timeline

Start: 2018-07-30
Primary completion: 2023-05
Completion: 2023-05

Publications

Davila DG, McKinstry-Wu A, Kelz MB, Proekt A. The Administration of Ketamine Is Associated with Dose-Dependent Stabilization of Cortical Dynamics in Humans. J Neurosci. 2025 May 14;45(20):e1545242025. doi: 10.1523/JNEUROSCI.1545-24.2025.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	—	Intravenous
Subject	Propofol	Small molecule	—	Intravenous

Indications

No indication recorded.