drugset / Trial / NCT03503058

Safety, Tolerability, Immunogenicity and Protective Efficacy of PfSPZ Vaccine and PfSPZ-CVac in Indonesian Adults Against Naturally-Transmitted Malaria

NCT03503058

RandomizedParallel-groupQuadruple-blindPrevention

Summary

The study is a double-blind, randomized, placebo-controlled, Phase 2 clinical trial that will assess the safety, tolerability, immunogenicity and protective efficacy of PfSPZ Vaccine and PfSPZ-CVac against naturally occurring malaria in healthy Indonesian soldiers deployed to eastern Indonesia.

Timeline

Start
2022-05-07
Primary completion
2024-02-27
Completion
2024-02-27

Drugs

EvaluationDrugModalityDoseRoute
Comparator Chloroquine Small molecule 5 mg/kg Oral
Subject PfSPZ Challenge Vaccine 200000 unknown Other
Subject PfSPZ Vaccine Vaccine 900000 unknown Other

Indications