Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments(SMART-CAT)

Summary

This study is a sequential multiple-assignment randomized trial (RCT) of antipsychotic medication treatment in first-episode schizophrenia patients in the real-world settings.Through analysis of treatment efficacy rate and adverse reactions and pharmacoeconomic evaluation, this project intends to provide evidence for the selection of antipsychotics in FES patients as well as the efficacy and safety of using clozapine in the early phase of schizophrenia treatment by comparing with other SGAs.

Timeline

Start

2019-02-12

Primary completion

2023-09-27

Completion

2023-09-27

Publications

• Li X, Lu C, Zhai Z, Smith RC, Zhang S, Wang H, Wang C, Yao Z, Chen Z, Xu X, Xie S, Feng T, Gao T, Dong Y, Zhuo K, Xiang Q, Jin H, Davis JM, Jiang K, Xu Y, Leucht S, Liu D. Clozapine After 1 Failed Antipsychotic Drug Trial in First-Episode Psychosis: A Randomized Clinical Trial. JAMA Psychiatry. 2026 Jun 1;83(6):570-580. doi: 10.1001/jamapsychiatry.2026.0086.
• Li X, Guo X, Fan X, Feng T, Wang C, Yao Z, Xu X, Chen Z, Wang H, Xie S, He J, Zhuo K, Xiang Q, Cen H, Wang J, Smith RC, Jin H, Keshavan MS, Marder SR, Davis JM, Jiang K, Xu Y, Liu D. Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments (SMART-CAT) in first-episode schizophrenia patients: Rationale and trial design. Schizophr Res. 2021 Apr;230:87-94. doi: 10.1016/j.schres.2020.11.010. Epub 2020 Dec 2.

Drugs

Indications