Decision Making Study in Young and Middle-Aged Adults: Part II

Summary

Financial decisions are made during pre-retirement age that can influence financial well-being for the rest of an individual's life. This proposal aims to construct a more comprehensive model of the specific psychological and neural mechanisms that support financial decisions in young adulthood and late middle age. In Part 1 of this study (covered in Institutional Review Board (IRB) # 141812), middle-age and young adults complete basic cognitive, motivational, and decision making tasks and are studied with functional magnetic resonance imaging (fMRI) to determine the relation between neural circuit activation and individual and age-related differences in decision making. In part II of the study, aspects of dopamine functioning are studied using positron emission tomography (PET) scanning to determine whether individual differences in dopamine functions are related to the decision-making and fMRI measures collected in Part 1 of the study. Dopamine measures include baseline D2 receptor availability, amphetamine induced dopamine release and dopamine transporter (DAT) levels, which provides a more comprehensive evaluation of dopamine functions than in prior studies linking individual differences in dopamine to behavioral, cognitive or decision-making traits.

Timeline

Start

2016-03-31

Primary completion

2018-05-15

Completion

2018-05-15

Publications

• Background Li SC, Lindenberger U, Sikstrom S. Aging cognition: from neuromodulation to representation. Trends Cogn Sci. 2001 Nov 1;5(11):479-486. doi: 10.1016/s1364-6613(00)01769-1.
• Background Braver TS, Barch DM. A theory of cognitive control, aging cognition, and neuromodulation. Neurosci Biobehav Rev. 2002 Nov;26(7):809-17. doi: 10.1016/s0149-7634(02)00067-2.
• Background Kaasinen V, Rinne JO. Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease. Neurosci Biobehav Rev. 2002 Nov;26(7):785-93. doi: 10.1016/s0149-7634(02)00065-9.
• Background Buckholtz JW, Treadway MT, Cowan RL, Woodward ND, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Shelby ES, Smith CE, Kessler RM, Zald DH. Dopaminergic network differences in human impulsivity. Science. 2010 Jul 30;329(5991):532. doi: 10.1126/science.1185778.
• Background Buckholtz JW, Treadway MT, Cowan RL, Woodward ND, Benning SD, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Shelby ES, Smith CE, Cole D, Kessler RM, Zald DH. Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nat Neurosci. 2010 Apr;13(4):419-21. doi: 10.1038/nn.2510. Epub 2010 Mar 14.
• Background Zald DH, Cowan RL, Riccardi P, Baldwin RM, Ansari MS, Li R, Shelby ES, Smith CE, McHugo M, Kessler RM. Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans. J Neurosci. 2008 Dec 31;28(53):14372-8. doi: 10.1523/JNEUROSCI.2423-08.2008.
• Background Ashby FG, Isen AM, Turken AU. A neuropsychological theory of positive affect and its influence on cognition. Psychol Rev. 1999 Jul;106(3):529-50. doi: 10.1037/0033-295x.106.3.529.
• Background Carstensen LL, Turan B, Scheibe S, Ram N, Ersner-Hershfield H, Samanez-Larkin GR, Brooks KP, Nesselroade JR. Emotional experience improves with age: evidence based on over 10 years of experience sampling. Psychol Aging. 2011 Mar;26(1):21-33. doi: 10.1037/a0021285.
• Background Carstensen LL, Pasupathi M, Mayr U, Nesselroade JR. Emotional experience in everyday life across the adult life span. J Pers Soc Psychol. 2000 Oct;79(4):644-55.
• Background Charles ST, Carstensen LL. Emotion regulation and aging. Gross JJ, editor. Handbook of Emotion Regulation. New York: Guilford Press; 2007. p. 307-20.
• Background Carstensen LL. The influence of a sense of time on human development. Science. 2006 Jun 30;312(5782):1913-5. doi: 10.1126/science.1127488.
• Background Carstensen LL, Isaacowitz DM, Charles ST. Taking time seriously. A theory of socioemotional selectivity. Am Psychol. 1999 Mar;54(3):165-81. doi: 10.1037//0003-066x.54.3.165.
• Background Samanez-Larkin GR, Carstensen LL. Socioemotional Functioning and the Aging Brain. Decety J, Cacioppo JT, editors. The Handbook of Social Neuroscience. Oxford University Press; 2011. p. 507-21.
• Background Backman L, Ginovart N, Dixon RA, Wahlin TB, Wahlin A, Halldin C, Farde L. Age-related cognitive deficits mediated by changes in the striatal dopamine system. Am J Psychiatry. 2000 Apr;157(4):635-7. doi: 10.1176/ajp.157.4.635.
• Background Volkow ND, Ding YS, Fowler JS, Wang GJ, Logan J, Gatley SJ, Hitzemann R, Smith G, Fields SD, Gur R. Dopamine transporters decrease with age. J Nucl Med. 1996 Apr;37(4):554-9.
• Background Wang GJ, Volkow ND, Logan J, Fowler JS, Schlyer D, MacGregor RR, Hitzemann RJ, Gur RC, Wolf AP. Evaluation of age-related changes in serotonin 5-HT2 and dopamine D2 receptor availability in healthy human subjects. Life Sci. 1995;56(14):PL249-53. doi: 10.1016/0024-3205(95)00066-f.
• Background Volkow ND, Logan J, Fowler JS, Wang GJ, Gur RC, Wong C, Felder C, Gatley SJ, Ding YS, Hitzemann R, Pappas N. Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism. Am J Psychiatry. 2000 Jan;157(1):75-80. doi: 10.1176/ajp.157.1.75.
• Background Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, MacGregor RR, Schlyer DJ, Hitzemann R, Wolf AP. Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol. Psychiatry Res. 1996 May 31;67(1):11-6. doi: 10.1016/0925-4927(96)02809-0.
• Background Volkow ND, Wang GJ, Fowler JS, Ding YS, Gur RC, Gatley J, Logan J, Moberg PJ, Hitzemann R, Smith G, Pappas N. Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging. Ann Neurol. 1998 Jul;44(1):143-7. doi: 10.1002/ana.410440125.
• Background Kessler RM. Imaging methods for evaluating brain function in man. Neurobiol Aging. 2003 May-Jun;24 Suppl 1:S21-35; discussion S37-9. doi: 10.1016/s0197-4580(03)00047-2.
• Background Christian BT, Narayanan T, Shi B, Morris ED, Mantil J, Mukherjee J. Measuring the in vivo binding parameters of [18F]-fallypride in monkeys using a PET multiple-injection protocol. J Cereb Blood Flow Metab. 2004 Mar;24(3):309-22. doi: 10.1097/01.WCB.0000105020.93708.DD.
• Background Christian BT, Narayanan TK, Shi B, Mukherjee J. Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [(18)F]fallypride in nonhuman primates. Synapse. 2000 Oct;38(1):71-9. doi: 10.1002/1098-2396(200010)38:13.0.CO;2-2.
• Background Mukherjee J, Christian BT, Dunigan KA, Shi B, Narayanan TK, Satter M, Mantil J. Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors. Synapse. 2002 Dec 1;46(3):170-88. doi: 10.1002/syn.10128.
• Background Mukherjee J, Yang ZY, Brown T, Lew R, Wernick M, Ouyang X, Yasillo N, Chen CT, Mintzer R, Cooper M. Preliminary assessment of extrastriatal dopamine D-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, 18F-fallypride. Nucl Med Biol. 1999 Jul;26(5):519-27. doi: 10.1016/s0969-8051(99)00012-8.
• Background Rieck RW, Ansari MS, Whetsell WO Jr, Deutch AY, Kessler RM. Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies. Neuropsychopharmacology. 2004 Feb;29(2):362-72. doi: 10.1038/sj.npp.1300336.
• Background Li SC, Lindenberger U, Backman L. Dopaminergic modulation of cognition across the life span. Neurosci Biobehav Rev. 2010 Apr;34(5):625-30. doi: 10.1016/j.neubiorev.2010.02.003. Epub 2010 Feb 10. No abstract available.
• Background Eppinger B, Hammerer D, Li SC. Neuromodulation of reward-based learning and decision making in human aging. Ann N Y Acad Sci. 2011 Oct;1235:1-17. doi: 10.1111/j.1749-6632.2011.06230.x.
• Background Mohr PN, Li SC, Heekeren HR. Neuroeconomics and aging: neuromodulation of economic decision making in old age. Neurosci Biobehav Rev. 2010 Apr;34(5):678-88. doi: 10.1016/j.neubiorev.2009.05.010. Epub 2009 Jun 6.
• Background Kaasinen V, Vilkman H, Hietala J, Nagren K, Helenius H, Olsson H, Farde L, Rinne J. Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain. Neurobiol Aging. 2000 Sep-Oct;21(5):683-8. doi: 10.1016/s0197-4580(00)00149-4.
• Background West RL. An application of prefrontal cortex function theory to cognitive aging. Psychol Bull. 1996 Sep;120(2):272-92. doi: 10.1037/0033-2909.120.2.272.
• Background Hicks LH, Birren JE. Aging, brain damage, and psychomotor slowing. Psychol Bull. 1970 Dec;74(6):377-96. doi: 10.1037/h0033064. No abstract available.
• Background MacPherson SE, Phillips LH, Della Sala S. Age, executive function, and social decision making: a dorsolateral prefrontal theory of cognitive aging. Psychol Aging. 2002 Dec;17(4):598-609.
• Background Rubin DC. Frontal-Striatal Circuits in Cognitive Aging: Evidence for Caudate Involvement. Aging, Neuropsychology, and Cognition. 1999;6(4):241-59.
• Background Salthouse TA. Why are there different age relations in cross-sectional and longitudinal comparisons of cognitive functioning? Curr Dir Psychol Sci. 2014 Aug 1;23(4):252-256. doi: 10.1177/0963721414535212.
• Background Raz N. The Aging Brain Observed in Vivo: Differential Changes and Their Modifiers. Cabeza R, Nyberg L, Park D, editors. Cognitive neuroscience of aging: Linking cognitive and cerebral aging. Oxford University Press, New York, NY, US; 2005. p. 19-57.
• Background Wardle MC, Treadway MT, Mayo LM, Zald DH, de Wit H. Amping up effort: effects of d-amphetamine on human effort-based decision-making. J Neurosci. 2011 Nov 16;31(46):16597-602. doi: 10.1523/JNEUROSCI.4387-11.2011.
• Background Treadway MT, Buckholtz JW, Cowan RL, Woodward ND, Li R, Ansari MS, Baldwin RM, Schwartzman AN, Kessler RM, Zald DH. Dopaminergic mechanisms of individual differences in human effort-based decision-making. J Neurosci. 2012 May 2;32(18):6170-6. doi: 10.1523/JNEUROSCI.6459-11.2012.
• Background Samanez-Larkin GR, Mata R, Radu PT, Ballard IC, Carstensen LL, McClure SM. Age Differences in Striatal Delay Sensitivity during Intertemporal Choice in Healthy Adults. Front Neurosci. 2011 Nov 16;5:126. doi: 10.3389/fnins.2011.00126. eCollection 2011.
• Background Riccardi P, Li R, Ansari MS, Zald D, Park S, Dawant B, Anderson S, Doop M, Woodward N, Schoenberg E, Schmidt D, Baldwin R, Kessler R. Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans. Neuropsychopharmacology. 2006 May;31(5):1016-26. doi: 10.1038/sj.npp.1300916.
• Background Kessler RM, Mason NS, Jones C, Ansari MS, Manning RF, Price RR. [18F]N-allyl-5-fluoropropylepidepride (fallypride): radiation dosimetry, quantification of striatal and extrastriatal dopamine receptors in man. NeuroImage. 2000Aug.26;11:S32.
• Background Woodward ND, Zald DH, Ding Z, Riccardi P, Ansari MS, Baldwin RM, Cowan RL, Li R, Kessler RM. Cerebral morphology and dopamine D2/D3 receptor distribution in humans: a combined [18F]fallypride and voxel-based morphometry study. Neuroimage. 2009 May 15;46(1):31-8. doi: 10.1016/j.neuroimage.2009.01.049. Epub 2009 Feb 5.
• Background Riccardi P, Baldwin R, Salomon R, Anderson S, Ansari MS, Li R, Dawant B, Bauernfeind A, Schmidt D, Kessler R. Estimation of baseline dopamine D2 receptor occupancy in striatum and extrastriatal regions in humans with positron emission tomography with [18F] fallypride. Biol Psychiatry. 2008 Jan 15;63(2):241-4. doi: 10.1016/j.biopsych.2007.03.022. Epub 2007 Jun 27.
• Background Zald DH, Woodward ND, Cowan RL, Riccardi P, Ansari MS, Baldwin RM, Cowan RL, Smith CE, Hakyemez H, Li R, Kessler RM. The interrelationship of dopamine D2-like receptor availability in striatal and extrastriatal brain regions in healthy humans: a principal component analysis of [18F]fallypride binding. Neuroimage. 2010 May 15;51(1):53-62. doi: 10.1016/j.neuroimage.2010.02.006. Epub 2010 Feb 10.
• Background Riccardi P, Zald D, Li R, Park S, Ansari MS, Dawant B, Anderson S, Woodward N, Schmidt D, Baldwin R, Kessler R. Sex differences in amphetamine-induced displacement of [(18)F]fallypride in striatal and extrastriatal regions: a PET study. Am J Psychiatry. 2006 Sep;163(9):1639-41. doi: 10.1176/ajp.2006.163.9.1639.
• Background Stroop JE. Studies of interference in serial verbal reactions. J Exp Psychol Gen. 1935;:18643-62.
• Background Wechsler D. Wechsler Memory Scale, 3rd edition. San Antonio, TX: Psychological Corporation; 1997.
• Background Wechsler D. Wechsler Adult Intelligence Scale, 3rd Edition. San Antonio, TX: Psychological Corporation; 1997.
• Background Benton AL. Development of a multilingual aphasia battery. Progress and problems. J Neurol Sci. 1969 Jul-Aug;9(1):39-48. doi: 10.1016/0022-510x(69)90057-4. No abstract available.
• Background Rogers R, Monsell S. Costs of a predictible switch between simple cognitive tasks. Journal of experimental psychology: General. 1995;124(2):207-31.
• Background Bryden PJ, Roy EA. A new method of administering the Grooved Pegboard Test: performance as a function of handedness and sex. Brain Cogn. 2005 Aug;58(3):258-68. doi: 10.1016/j.bandc.2004.12.004.
• Background Ruff RM, Parker SB. Gender- and age-specific changes in motor speed and eye-hand coordination in adults: normative values for the Finger Tapping and Grooved Pegboard Tests. Percept Mot Skills. 1993 Jun;76(3 Pt 2):1219-30. doi: 10.2466/pms.1993.76.3c.1219.
• Background Park DC, Schwarz N, editors. Cognitive aging: A primer. Psychology Press, New York, NY, US; 2000.
• Background Buckner RL. Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron. 2004 Sep 30;44(1):195-208. doi: 10.1016/j.neuron.2004.09.006.
• Background Luciana M, Depue RA, Arbisi P, Leon A. Facilitation of working memory in humans by a d2 dopamine receptor agonist. J Cogn Neurosci. 1992 Winter;4(1):58-68. doi: 10.1162/jocn.1992.4.1.58.
• Background Servan-Schreiber D, Bruno RM, Carter CS, Cohen JD. Dopamine and the mechanisms of cognition: Part I. A neural network model predicting dopamine effects on selective attention. Biol Psychiatry. 1998 May 15;43(10):713-22. doi: 10.1016/s0006-3223(97)00448-4.
• Background Lipkus IM, Samsa G, Rimer BK. General performance on a numeracy scale among highly educated samples. Med Decis Making. 2001 Jan-Feb;21(1):37-44. doi: 10.1177/0272989X0102100105.
• Background Moustafa AA, Cohen MX, Sherman SJ, Frank MJ. A role for dopamine in temporal decision making and reward maximization in parkinsonism. J Neurosci. 2008 Nov 19;28(47):12294-304. doi: 10.1523/JNEUROSCI.3116-08.2008.
• Background Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol. 1988 Jun;54(6):1063-70. doi: 10.1037//0022-3514.54.6.1063.
• Background Carver CS, White TL. Behavioral Inhibition, Behavioral Activation, and Affective Responses to Impending Reward and Punishment: The BIS/BAS Scales. Journal of Personality and Social Psychology. 1994;67(2):319-33.
• Background Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol. 1995 Nov;51(6):768-74. doi: 10.1002/1097-4679(199511)51:63.0.co;2-1.
• Background Cloninger CR, Przybeck TR, Svrakic DM. The Tridimensional Personality Questionnaire: U.S. normative data. Psychol Rep. 1991 Dec;69(3 Pt 1):1047-57. doi: 10.2466/pr0.1991.69.3.1047.
• Background Costa PT, McCrae RR. Normal personality assessment in clinical practice: The NEO Personality Inventory. Psychological Assessment. 1992Mar.;4(1):5-13.
• Background Diener E, Emmons RA, Larsen RJ, Griffin S. The Satisfaction With Life Scale. J Pers Assess. 1985 Feb;49(1):71-5. doi: 10.1207/s15327752jpa4901_13.
• Background Carstensen LL, Lang FR. Future Time Perspective Scale. 1995.
• Background Knutson B, Samanez-Larkin GR, Kuhnen CM. Gain and loss learning differentially contribute to life financial outcomes. PLoS One. 2011;6(9):e24390. doi: 10.1371/journal.pone.0024390. Epub 2011 Sep 6.
• Background Ersner-Hershfield H, Garton MT, Ballard K, Samanez-Larkin GR, Knutson B. Don't stop thinking about tomorrow: Individual differences in future self-continuity account for saving. Judgm Decis Mak. 2009 Jun 1;4(4):280-286.
• Background Samanez-Larkin GR, Levens SM, Perry LM, Dougherty RF, Knutson B. Frontostriatal white matter integrity mediates adult age differences in probabilistic reward learning. J Neurosci. 2012 Apr 11;32(15):5333-7. doi: 10.1523/JNEUROSCI.5756-11.2012.
• Background McClure SM, Laibson DI, Loewenstein G, Cohen JD. Separate neural systems value immediate and delayed monetary rewards. Science. 2004 Oct 15;306(5695):503-7. doi: 10.1126/science.1100907.
• Background Treadway MT, Buckholtz JW, Schwartzman AN, Lambert WE, Zald DH. Worth the 'EEfRT'? The effort expenditure for rewards task as an objective measure of motivation and anhedonia. PLoS One. 2009 Aug 12;4(8):e6598. doi: 10.1371/journal.pone.0006598.
• Background Platt ML, Huettel SA. Risky business: the neuroeconomics of decision making under uncertainty. Nat Neurosci. 2008 Apr;11(4):398-403. doi: 10.1038/nn2062. Epub 2008 Mar 26.
• Background Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res. 1996 Jun;29(3):162-73. doi: 10.1006/cbmr.1996.0014.

Drugs

Indications

No indication recorded.