drugset / Trial / NCT03515824

Study of MK-1697 in Participants With Advanced Solid Tumors (MK-1697-001)

NCT03515824 ↗

Phase 1 Terminated 22 enrolled Merck Sharp & Dohme LLC
Non-randomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to evaluate the safety and preliminary efficacy of MK-1697. There are 2 parts in this study: dose escalation to determine the recommended phase 2 dose (RP2D) and confirm the RP2D (Part A) and cohort expansion to determine preliminary efficacy in participants with colorectal cancer (CRC) or head and neck squamous cell cancer (HNSCC) (Part B). No formal hypothesis testing will be done in this study.

Timeline

Start
2018-08-13
Primary completion
2020-02-18
Completion
2020-02-18

Outcome

Outcome not reported

Stopped (Business): “Business Reasons”

Drugs

EvaluationDrugModalityDoseRoute
Subject MK-1697 Unknown 20 mg Intravenous
Subject MK-1697 Unknown 65 mg Intravenous
Subject MK-1697 Unknown 200 mg Intravenous