drugset / Trial / NCT03521960

Buspirone for Opioid Tapering

NCT03521960

Phase 1 Completed 18 enrolled Johns Hopkins University
RandomizedParallel-groupQuadruple-blindTreatment

Summary

This is a pilot study to collect preliminary data to support a grant application. The goal of the study is to evaluate whether the Food and Drug Administration (FDA)-approved and generically-available medication buspirone reduces symptoms of opioid withdrawal among patients undergoing a clinically-indicated and supervised taper from their opioid pain medications. This is premised on strong preclinical scientific support but has not yet be well-examined in humans.

Timeline

Start
2018-05-30
Primary completion
2020-06-30
Completion
2020-06-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Buspirone Small molecule 15 mg Oral