A Study Comparing Recurrent Use of MSIR, Percocet, and Vicodin at Discharge From the ED
Summary
This is a prospective randomized, clinical trial comparing recurrent use of Morphine Sulfate Immediate Release (MSIR), Oxycodone/Acetaminophen (Percocet), and Hydrocodone/Acetaminophen (Vicodin) at discharge from the emergency department for opioid-naive adult patients presenting with moderate-to-severe pain. At discharge, patients will be randomized to receive either 5 mg of Oxycodone/Acetaminophen (Percocet) tablet 4 times a day for 5 days, 5 mg of Hydrocodone/Acetaminophen (Vicodin) tablet 4 times a day for 5 days, or 15 mg Morphine Sulfate Immediate Release (MSIR) tablet 4 times a day for 5 days. At 1 month, 3 months, and 6 months patients' prescription's history will be accessed by using the DoctorFirst Drug Database to determine the recurrent use that will serve as a surrogate marker of likeability and abuse liability of each prescribed opioid.
Timeline
- Start
- 2019-09-01
- Primary completion
- 2021-12-31
- Completion
- 2021-12-31
Outcome
Outcome not reported
Stopped: “The ED physicians no longer prescribe opioids at discharge; not feasible to conduct the study”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Hydrocodone/Acetaminophen | Unknown | 5 mg | — |
| Comparator | Morphine Sulfate Immediate Release | Unknown | 15 mg | — |
| Comparator | Oxycodone/Acetaminophen | Unknown | 5 mg | — |
Indications
No indication recorded.