Glucocorticoid Inflammation Paradox in Human Skeletal Muscle

Summary

In this project, we propose to investigate the metabolic consequences of glucocorticoid therapy, given orally as a 6 day Medrol Dose pack, on human skeletal muscle as measured by western blotting and PCR and skeletal muscle mitochondrial capacity as measured by High-Resolution Respirometry in healthy individuals. Medrol is an FDA approved drug with many clinical indications.

Timeline

Start

2019-06-01

Primary completion

2020-05-01

Completion

2020-12-01

Drugs

Indications