drugset / Trial / NCT03531762
Effect of a Proton Pump Inhibitor on the PK of Tepotinib
RandomizedCrossoverOpen-labelOther
Summary
This study was investigated in healthy participants (i) the effect of omeprazole (proton pump inhibitor) co-administration on the single dose pharmacokinetics (PK) of tepotinib under fed conditions, and (ii) the effect of food on the single dose PK of tepotinib after co-administration of omeprazole and tepotinib. Furthermore, the study assessed the safety and tolerability of tepotinib alone and upon co-administration of omeprazole.
Timeline
- Start
- 2018-05-14
- Primary completion
- 2018-07-02
- Completion
- 2018-07-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Omeprazole | Other / unclassified | 40 mg | — |
| Subject | Tepotinib | Small molecule | 500 mg | Oral |
Indications
No indication recorded.