Bismuth Subsalicylate's Role in the Prevention of Travelers' Diarrhea

Summary

The purpose of this study is to determine if the use of prophylactic bismuth subsalicylate (BSS) has an effect on the acquisition of travelers' diarrhea (TD) or antimicrobial resistance (AMR) genes in fecal samples among international travelers who departed from the United States to South East Asia, South Central Asia, or Africa. Our hypotheses will be tested using a double-blinded, placebo controlled randomized clinical trial with participants from a pre-travel health clinic in the United States.

Timeline

Start

2018-05-20

Primary completion

2023-11-01

Completion

2026-04-29

Publications

• Gibb RD, Brum JM, Sloan KJ, Pitz AM, Circello BT, Grayling RA. Revisiting the efficacy of bismuth subsalicylate for the prevention of traveller's diarrhoea. J Travel Med. 2025 Oct 1;32(6):taaf076. doi: 10.1093/jtm/taaf076.

Drugs

Indications