Cockroach Immunotherapy in Children and Adolescents

Summary

Scientific evidence has shown that, over the past two decades, the combination of cockroach allergy and cockroach exposure is one of the most important factors contributing to the dramatic increase in asthma morbidity seen in inner city children with asthma. Therefore, a major goal of the Inner City Asthma Consortium (ICAC) is to evaluate the efficacy of cockroach immunotherapy in inner city asthma. The primary objective of the study is to determine if the response to nasal allergen challenge (NAC) will be changed with treatment with cockroach subcutaneous immunotherapy (SCIT) treatment.

Timeline

Start

2018-07-16

Primary completion

2022-06-02

Completion

2022-06-03

Outcome

Missed primary endpoint

registry analysis (superiority test); Cockroach SCIT vs Placebo; p = 0.63; Least Square Mean Difference -0.23 (95% CI -1.15 to 0.70); ANCOVA NCT03541187 ↗

Publications

• Dunaway LE, Da Silva Antunes R, Pomes A, Altman MC, Glesner J, Benson B, Cho K, Zoratti EM, Wood RA, Little FF, Pongracic JA, Hershey GKK, Sherenian MG, Chambliss JM, Gill MA, Liu AH, Lamm C, Kattan M, Bacharier LB, Sheehan WJ, Busse P, Togias A, Wheatley LM, Becker PM, Visness CM, Busse WW, Sette A, Jackson DJ. Correlates of cockroach nasal challenge responsiveness among sensitized urban children with asthma. J Allergy Clin Immunol Glob. 2026 Mar 18;5(3):100684. doi: 10.1016/j.jacig.2026.100684. eCollection 2026 May.
• da Silva Antunes R, Sutherland A, Abawi A, Frazier A, Pomes A, Glesner J, Slater JE, Mindaye ST, Cho K, Zhou G, Ozanne MV, Calatroni A, Visness CM, Altman MC, Wood RA, O'Connor GT, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Gill M, Searing D, Liu AH, Zoratti E, Kattan M, Busse PJ, Sheehan W, Bacharier LB, Teach SJ, Wheatley LM, Togias A, Busse WW, Jackson DJ, Sette A. Cockroach immunotherapy modulates dominant T-cell responses independent of allergen extract content. J Allergy Clin Immunol. 2025 Nov;156(5):1303-1313. doi: 10.1016/j.jaci.2025.07.011. Epub 2025 Jul 24.

Drugs

Indications