drugset

drugset / Trial / NCT03545243

PPI and Microbiome in Healthy Volunteers and Functional Dyspepsia

NCT03545243 ↗

Phase 4 Completed 79 enrolled Universitaire Ziekenhuizen KU Leuven

Non-randomizedParallel-groupOpen-labelTreatment

Summary

Prospective interventional study of the effect of PPI on the duodenal microbiome in healthy volunteers and functional dyspepsia patients

Timeline

Start: 2018-04-23
Primary completion: 2020-03-08
Completion: 2020-09-22

Publications

Wauters L, Ceulemans M, Frings D, Lambaerts M, Accarie A, Toth J, Mols R, Augustijns P, De Hertogh G, Van Oudenhove L, Tack J, Vanuytsel T. Proton Pump Inhibitors Reduce Duodenal Eosinophilia, Mast Cells, and Permeability in Patients With Functional Dyspepsia. Gastroenterology. 2021 Apr;160(5):1521-1531.e9. doi: 10.1053/j.gastro.2020.12.016. Epub 2020 Dec 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pantoprazole	Other / unclassified	40 mg	Oral

Indications