drugset / Trial / NCT03559868
Inhibition of Sterile Inflammation by Digoxin
Phase 1
Completed
45 enrolled
Yale University
National Institute on Alcohol Abuse and Alcoholism (NIAAA) · collab
Non-randomizedParallel-groupSingle-blindBasic science
Summary
To investigate the effect of digoxin on pyruvate kinase isoform 2 (PKM2) binding to pro-inflammatory loci and innate immune inflammatory responses in the peripheral blood in healthy subjects.
Timeline
- Start
- 2021-03-01
- Primary completion
- 2023-05-05
- Completion
- 2023-05-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Digoxin | Other / unclassified | 0.15 ug/kg | Oral |
| Comparator | Digoxin | Other / unclassified | 3 ug/kg | Oral |