Intraperitoneal Infusion of EpCAM CAR-T Cell in Advanced Gastric Cancer With Peritoneal Metastasis (WCH-GC-CART)

Phase 1 Unknown 40 enrolled Jian-Kun Hu

Non-randomizedParallel-groupOpen-labelTreatment

Summary

To investigate the safety and efficacy of intraperitoneal infusion of EpCAM CAR-T cell in advanced gastric cancer with peritoneal metastasis by a prospective nonrandomized controlled trial.

Timeline

Start: 2018-08-30
Primary completion: 2019-12-31
Completion: 2022-12-31

Publications

Sarkar T, Sarkar T, Goswami M, Robaszkiewicz A, Sarkar K. Integrated transcriptome analysis and in silico investigations identify KHDRBS3 to target with steroidal lactone in paclitaxel resistance breast cancer. Biochem Biophys Res Commun. 2025 Sep 1;777:152332. doi: 10.1016/j.bbrc.2025.152332. Epub 2025 Jul 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	CAR-T cells targeting EpCAM	Cell therapy	—	Other

Intraperitoneal Infusion of EpCAM CAR-T Cell in Advanced Gastric Cancer With Peritoneal Metastasis (WCH-GC-CART)

Summary

Timeline

Publications

Drugs

Indications