drugset
drugset / Trial / NCT03574857

Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance

NCT03574857 ↗

Phase 4 Terminated 5 enrolled University of Virginia
RandomizedParallel-groupOpen-labelTreatment

Summary

The primary objective of the study is to compare efficacy of metolazone and chlorothiazide as add-on therapy in patients refractory to loop diuretics with heart failure with a reduced ejection fraction (HFrEF). This will be a single-center randomized pilot study.

Timeline

Start
2018-06-01
Primary completion
2021-01-01
Completion
2021-01-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Chlorothiazide Small molecule 500 mg Intravenous
Comparator Metolazone Small molecule 5 mg Oral

Indications

symptomatic heart failure