Effect of Two Toothpastes on Bacteria in Saliva

Summary

This study investigated the ability of two zinc-containing toothpaste formulations (Zinc A and Zinc B) to reduce the level of bacteria in saliva in the two-hour period after their use, compared to the effect of rinsing with water alone.

Timeline

Start

2014-11-04

Primary completion

2014-11-27

Completion

2014-11-27

Outcome

Mixed primary results

registry analysis (superiority test); Zinc-A Toothpaste vs Mineral Water; p = 0.1787; Mean Difference (Final Values) -0.3252 (95% CI -0.8101 to 0.1596); ANCOVA NCT03587428 ↗

registry analysis (superiority test); Zinc-B Toothpaste vs Mineral Water; p = 0.0063; Mean Difference (Final Values) -0.7037 (95% CI -1.1886 to -0.2187); ANCOVA NCT03587428 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Zinc-A toothpaste	Other / unclassified	6 g	Oral
Subject	Zinc-B toothpaste	Other / unclassified	6 g	Oral

Indications

No indication recorded.