Effect of Stomach Reduction Surgery on the Parameters of Amoxicillin

Completed 8 enrolled Drug Research and Development Center, Federal University of Ceara University of Campinas, Brazil · collab

NaSingle-groupOpen-labelBasic science

Summary

The objective of this study was to evaluate the impact of bariatric surgery on the pharmacokinetics of amoxicillin. Methods: This study was performed as a randomized, open-label, single-dose clinical trial, with two periods of treatment, in which obese subjects (n=8) received amoxicillin 500 mg capsule orally before and 2 months after the Roux-en-Y gastric bypass surgery. The amoxicillin plasma concentration was determined by liquid chromatography coupled to mass spectrometry (LC-MS/MS).

Timeline

Start: 2016-06-24
Primary completion: 2017-04-03
Completion: 2017-04-03

Publications

Rocha MBS, De Nucci G, Lemos FN, de Albuquerque Lima Babadopulos RF, Rohleder AVP, Fechine FV, Antunes NJ, Mendes GD, do Nascimento DF, de Moraes MO, de Moraes MEA. Impact of Bariatric Surgery on the Pharmacokinetics Parameters of Amoxicillin. Obes Surg. 2019 Mar;29(3):917-927. doi: 10.1007/s11695-018-3591-3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Amoxicillin	Other / unclassified	500 mg	Oral

Indications

No indication recorded.