drugset / Trial / NCT03591471
Study on Children Henoch-Schönlein Purpura Nephritis With TCM Multistep Treatment
Phase 1/2
Unknown
500 enrolled
Henan University of Traditional Chinese Medicine
Affiliated Hospital of Yunnan University of Traditional Chinese Medicine · collabChengdu University of Traditional Chinese Medicine · collabChildren's Hospital of Fudan University · collabPeking University First Hospital · collabShanghai Children's Hospital · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to determine the optimum dosage and application method of Glycosides Of Tripterygium Wilfordii Hook(GTW) for Henoch-Schönlein Purpura Nephritis(HSPN) in children, and develop into the normal treatment protocols for Henoch-Schönlein Purpura Nephritis in children.
Timeline
- Start
- 2014-09
- Primary completion
- 2018-12
- Completion
- 2018-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Benazepril | Unknown | 5 mg | — |
| Comparator | Benazepril | Unknown | 10 mg | — |
| Subject | Chinese herbs based on syndrome differentiation | Traditional medicine (herbal / TCM) | — | — |
| Comparator | Dipyridamole | Other / unclassified | 3 mg/kg | — |
| Subject | Glycosides Of Tripterygium Wilfordii Hook | Traditional medicine (herbal / TCM) | 1 mg/kg | — |
| Comparator | Prednisone | Other / unclassified | 2 mg/kg | — |
| Subject | Sodium tanshinone IIA sulfonate | Small molecule | 1 mg/kg | Intravenous |