Cannabinoids for Pain Control During Medical Abortion

Phase 4 Completed 72 enrolled Oregon Health and Science University Society of Family Planning · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The objective of this study is to determine if a synthetic cannabis derivative, dronabinol, in addition to ibuprofen, decreases maximum pain scores compared to ibuprofen and placebo in women undergoing medical abortion. Results of this study will help providers counsel patients regarding cannabis use during medical abortion.

Timeline

Start: 2018-11-01
Primary completion: 2019-05-07
Completion: 2019-05-28

Outcome

Missed primary endpoint

paper We found no difference between groups in the median maximum pain score reported (dronabinol 7 [interquartile range 6-8], placebo 7 [interquartile range 5-8], P=.82) PMID 32459420 ↗

Publications

Colwill AC, Alton K, Bednarek PH, Bayer LL, Jensen JT, Garg B, Beardsworth K, Edelman A. Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial. Obstet Gynecol. 2020 Jun;135(6):1289-1295. doi: 10.1097/AOG.0000000000003850.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dronabinol	Other / unclassified	5 mg	Oral

Indications

No indication recorded.