Piroxicam and Levonorgestrel Co-treatment for Emergency Contraception

Phase 2/3 Completed 860 enrolled Dr. Hang Wun Raymond Li The Family Planning Association of Hong Kong · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

This is a randomised controlled trial aimed at comparing the efficacy of levonorgestrel (LNG) co-administered with piroxicam or placebo for oral emergency contraception (EC). Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used as a pain-killer in inflammatory conditions. Efficacy will be measured as the percentage of pregnancies prevented.

Timeline

Start: 2018-08-20
Primary completion: 2022-10-05
Completion: 2022-10-05

Publications

Li RHW, Lo SST, Gemzell-Danielsson K, Fong CHY, Ho PC, Ng EHY. Oral emergency contraception with levonorgestrel plus piroxicam: a randomised double-blind placebo-controlled trial. Lancet. 2023 Sep 9;402(10405):851-858. doi: 10.1016/S0140-6736(23)01240-0. Epub 2023 Aug 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Piroxicam	Unknown	40 mg	Oral
Comparator	Levonorgestrel	Small molecule	1.5 mg	Oral

Indications

No indication recorded.