drugset / Trial / NCT03617133

Image Guided IMRT, Radiochemotherapy and MRI-based IGABT in Locally Advanced Cervical Cancer

NCT03617133 ↗

Phase 2 Recruiting 1000 enrolled Medical University of Vienna Aarhus University Hospital · collabAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · collabCambridge University Hospitals NHS Foundation Trust · collabCatharina Ziekenhuis Eindhoven · collabChulalongkorn University · collabComplejo Hospitalario de Navarra · collabCross Cancer Institute · collabErasmus Medical Center · collabFondazione IRCCS Istituto Nazionale dei Tumori, Milano · collabGustave Roussy, Cancer Campus, Grand Paris · collabHospital Clinic of Barcelona · collabInstitut Bergonié · collabInstitut Català d'Oncologia · collabInstitute of Oncology Ljubljana · collabLeiden University Medical Center · collabLiverpool Hospital, Sydney · collabLoyola University Chicago · collabLudwig-Maximilians - University of Munich · collabM.D. Anderson Cancer Center · collabMaastro Clinic, The Netherlands · collabMaisonneuve-Rosemont Hospital · collabMcGill University · collabMount Vernon Cancer Centre · collabNational Cancer Institute, Slovakia · collabNorth Estonia Medical Centre · collabOdense University Hospital · collabOslo University Hospital · collabPamela Youde Nethersole Eastern Hospital · collabPost Graduate Institute of Medical Education and Research, Chandigarh · collabPrincess Margaret Hospital, Canada · collabRadboud University Medical Center · collabRadiotherapiegroep · collabRegion Örebro County · collabRigshospitalet, Denmark · collabRoyal Marsden NHS Foundation Trust · collabSiriraj Hospital · collabSkane University Hospital · collabSt Thomas' Hospital, London · collabTata Memorial Centre · collabThe Christie NHS Foundation Trust · collabThe Leeds Teaching Hospitals NHS Trust · collabThe Netherlands Cancer Institute · collabTom Baker Cancer Centre · collabTuen Mun Hospital · collabUMC Utrecht · collabUniversitaire Ziekenhuizen KU Leuven · collabUniversity Hospital Heidelberg · collabUniversity Hospitals Bristol and Weston NHS Foundation Trust · collabUniversity Hospitals Coventry and Warwickshire NHS Trust · collabUniversity of Pittsburgh · collab
NaSingle-groupOpen-labelTreatment

Summary

The research group on adaptive image-guided radiotherapy for locally advanced cervical carcinoma completed the protocol for the EMBRACE II study in October 2018. This study will be carried out in the next few years at the University Clinic for Radiotherapy at the Medical University of Vienna and other international partner institutes. EMBRACE II builds on the findings of the current EMBRACE study. These are already implemented in everyday clinical practice in order to further improve the accuracy of the entire therapy of cervical carcinomas, using state-of-the-art techniques of tele- and brachytherapy. The aim of the EMBRACE II study is to maintain and enhance the excellent local tumor control as well as the nodal and systemic control for all tumor stages while minimizing the adverse reaction rates for all affected organs (rectum, sigmoid, urinary bladder, and vagina) to increase the quality of life of patients with cervical carcinomas.

Timeline

Start
2016-04
Primary completion
2021-12-31
Completion
2031-04

Drugs

EvaluationDrugModalityDoseRoute
Background Cisplatin Other / unclassified 40 mg/m2 —