Mannitol-Induced Cough Challenge in Healthy Controls and Subjects With Mild Allergic Asthma

Summary

The study aim is to investigate if changes in osmolarity using mannitol challenge can evoke coughing reproducibly in mild allergic asthmatics compared with healthy controls and if salbutamol can affect this. Phase 1 of this study is a reproducibility analysis of cough dose response to mannitol in a cohort of mild allergic asthmatics and healthy controls. Phase 2 is a double-blind, placebo-controlled analysis in mild allergic asthmatics assessing the effects of salbutamol on mannitol induced cough.

Timeline

Start

2019-01-11

Primary completion

2020-01-31

Completion

2020-01-31

Drugs

Indications